Thymus dysgenesis in nude (nu nu) mice.
نویسندگان
چکیده
منابع مشابه
Susceptibility of congenitally athymic (nude) mice to sporotrichosis.
Congenitally athymic (nu/nu) mice were found to be more susceptible to intravenous challenge with Sporothrix schenckii than their phenotypically normal (nu/+) littermates as measured by lethality and the number of viable yeast cells in the liver 7 days postinfection. Thymus reconstitution of nu/nu mice (nu/thy) conferred a significant degree of resistance to sporotrichosis. Immunization greatly...
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Organ-specific autoimmune diseases such as gastritis, oophoritis, thyroiditis, or insulitis developed in athymic nu/nu mice after engraftment of the thymus from euthymic nu/+ mice treated with cyclosporin A (CsA), a potent immuno-suppressant. The development of autoimmune disease in the nu/nu mice was prevented by inoculation of thymocyte suspensions prepared from normal nu/+ mice, but not by t...
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Restoration of T cell function of athymic BALB/c nu/nu mice was investigated after transplantation of xenogeneic thymic rudiments from 15-d-old embryonic rats into kidney subcapsule. The rudiments developed well and formed a proper thymus structure composed of donor epithelia and host lymphocytes. Examination of antibody responses to SRBC revealed that approximately half the normal number of in...
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A sensitive and specific enzyme-linked immunosorbent assay was designed to measure the kinetics of Trypanosoma musculi-specific immunoglobulin M (IgM) and IgG responses in mice. Serum was obtained from congenitally athymic (nude) mice, their phenotypically normal, thymus-bearing littermates (NLM), and thymus cell-repaired nude mice (Nu-TC) at 6-day intervals throughout T. musculi parasitemia. N...
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The course and outcome of intraperitoneally induced infections with the avirulent strain A7(74) of Semliki Forest virus have been studied in athymic 'nude' (nu/nu) mice, their heterozygous (nu/ + ) littermates and conventional Swiss A2G mice. The main distinguishing characteristics of the infection in the nu/nu mice were the persistence of virus in the brain after an initial phase of incomplete...
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ورودعنوان ژورنال:
- Journal of embryology and experimental morphology
دوره 24 3 شماره
صفحات -
تاریخ انتشار 1970